Selenium

Selenium is an essential trace mineral and an antioxidant, and is also necessary for normal functioning of the immune system.

Most absorbable form

Yeast-based selenium.

RDI

70 mcg

Deficiency

Selenium deficiency is linked to Keshan Disease, a disease where the main symptom is an enlarged heart and corresponding poor heart function. Malnutrition or mal-absorption of nutrients may cause deficiency. Total parenteral nutrition may also cause deficiency.

Overdose

Too much selenium over time can lead to selenosis. Symptoms of selenosis include gastrointestinal upset, hair loss, white blotchy nails and mild nerve damage. The upper limit on selenium supplements is about 400 mcg per day.

Synergists

Selenium enhances the anti-oxidant effect of Vitamin E.

Food Sources

Brazil nuts are the best source of selenium. Yeast, whole grains, and seafood are other sources.

Medicinal Purpose

Selenium supplements may lower the risk of certain types of cancer, such as prostate cancer. Selenium supplementation is also helpful in treating asthma.

Interactions with common drugs

People who take seizure medication should supplement their selenium. Selenium has been studied as a tool to minimize free radical damage from certain types of chemotherapy medications.

Recent Studies

Brooks JD, Metter EJ, Chan DW, Sokoll LJ, Landis P, Nelson WG, Muller D, Andres R, Carter HB. Plasma selenium level before diagnosis and the risk of prostate cancer development.

J Urol. 2001 Dec;166(6):2034-8.

CONCLUSIONS: Low plasma selenium is associated with a 4 to 5-fold increased risk of prostate cancer. These results support the hypothesis that supplemental selenium may reduce the risk of prostate cancer. Because plasma selenium decreases with patient age, supplementation may be particularly beneficial to older men.